Molecular regulation of myofibroblast formation
نویسندگان
چکیده
منابع مشابه
Molecular regulation of myofibroblast formation
Novel strategies are required to counteract tissue contractures characteristic for organ fibrosis, stroma reaction to tumors, host reaction to implants, and formation of hypertrophic scars as after burns. Key element for the development and progression of these pathologies is the excessive contractile force generated by a-smooth muscle actin (a-SMA)-expressing myofibroblasts. We can modulate my...
متن کاملRegulation of myofibroblast differentiation by cardiac glycosides.
Myofibroblast differentiation is a key process in pathogenesis of fibrotic diseases. Cardiac glycosides (ouabain, digoxin) inhibit Na(+)-K(+)-ATPase, resulting in increased intracellular [Na(+)]-to-[K(+)] ratio in cells. Microarray analysis suggested that increased intracellular [Na(+)]/[K(+)] ratio may promote the expression of cyclooxygenase-2 (COX-2), a critical enzyme in the synthesis of pr...
متن کاملFAK-dependent regulation of myofibroblast differentiation.
Fibroblasts and myofibroblasts both participate in wound healing. Transforming growth factor beta (TGFbeta) induces fibroblasts to differentiate into myofibroblasts, whereas fibroblast growth factor and heparin (FGF/h) induce myofibroblasts to "de-differentiate" into fibroblasts. TGFbeta induces expression of smooth muscle alpha actin (SMalphaA) and incorporation into in stress fibers, a phenot...
متن کاملPopulation Spatial Mobility: Monitoring, Methodology of Formation, Features of Regulation
Spatial mobility is a topical concept of analytical migration science, which makes it possible to assess the desires, readiness and capabilities of the population to move over certain distances and time. In the management of spatial mobility assessment requires the organization of systematic monitoring, which includes identifying the mobility potential in spatial and temporal interpretation, th...
متن کاملFormation and function of the myofibroblast during tissue repair.
It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event during wound healing and tissue repair. The high contractile force generated by myofibroblasts is beneficial for physiological tissue remodeling but detrimental for tissue function when it becomes excessive such as in hypertrophic scars, in virtually all fibrotic diseases and during stroma reaction ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2008
ISSN: 0906-6705,1600-0625
DOI: 10.1111/j.1600-0625.2008.00789_6.x